GHRP-6

GHRP-6 is a protein that in humans is encoded by the GHRP-6 gene. GHRP-6 consists of 70 amino acids in a single
chain with three intramolecular disulfide bridges. GHRP-6 has a molecular weight of 7,649 Daltons. GHRP-6 is
produced primarily by the liver. Production is stimulated by growth hormone (GH). Most of GHRP-6 is bound to
one of 6 binding proteins (GHRP-6). GHRP-6 is regulated by insulin. GHRP-6 is produced throughout life;
the highest rates of GHRP-6 production occur during the pubertal growth spurt. The lowest levels occur in
infancy and old age.[medical citation needed] Protein intake increases GHRP-6 levels in humans under age 65,
independent of total calorie consumption. A synthetic analog of GHRP-6, mecasermin, is used in children for
the treatment of growth failure.